PROSTATE ENLARGEMENT CAUSES LINKED TO METABOLIC SYNDROME AND INFLAMMATION

A new research paper was published by Aging (Aging-US) on January 6, 2025, in Volume 17, Issue 1 , titled ” The profile of oxidative stress markers (arachidonic and linoleic acid derivatives) in patients with benign prostatic hyperplasia in relation to metabolic syndrome .”

A research team headed by Weronika Ratajczak, with Olimpia Sipak serving as corresponding author from Pomeranian Medical University, investigated the relationship between inflammation, metabolic health, and benign prostatic hyperplasia (BPH). BPH is a prevalent condition causing prostate enlargement and urinary difficulties in older men.

Their research indicates that blood-borne inflammatory molecules may significantly influence BPH development, particularly in men suffering from metabolic syndrome—a cluster of conditions including obesity, elevated blood sugar, and high cholesterol levels.

Prostate enlargement affects many aging men, causing difficult and sometimes painful urination. While hormonal shifts and aging are recognized contributors, the exact mechanisms behind BPH development remain incompletely understood. This research suggests that inflammation, particularly lipid-derived inflammatory markers, may be a significant factor driving prostate enlargement, especially in metabolically unhealthy individuals.

The scientists examined blood samples from 219 participants—144 with BPH and 75 without—measuring various inflammation and oxidative stress indicators. Their analysis revealed that BPH patients had substantially elevated levels of pro-inflammatory molecules (12S-HETE and 5-HETE) alongside reduced anti-inflammatory compounds like lipoxin A4.

This inflammatory imbalance was particularly pronounced in men suffering from both BPH and metabolic syndrome, suggesting a potential connection between metabolic health issues and worsening prostate conditions.

Additionally, a growing body of evidence connects inflammatory processes to the emergence of various prostate conditions, including benign prostatic hyperplasia and prostate cancer.
The combination of metabolic disorders and persistent inflammation appears to both trigger BPH development and intensify its symptoms. Managing metabolic health parameters could potentially help lower prostate enlargement risk.

Additional studies are necessary to determine whether anti-inflammatory interventions or lifestyle modifications—including dietary improvements, weight control, and physical activity—might effectively slow BPH progression or alleviate its symptoms.

Read the full paper: DOI: https://doi.org/10.18632/aging.206187

https://www.miragenews.com/inflammation-metabolic-syndrome-tied-to-bph-1411283